Dr Gavin McCluskey, Clinical Research Fellow
Project: Validation of circulating exosomal diagnostic and prognostic biomarker candidates for Amyotrophic Lateral Sclerosis.Christina Vasilopoulou, PhD researcher
Project: Personalized medicine using computational analysis of omics data and molecular interaction networks.Ekene Anakor, Pharmacist & PhD researcher
Project: Biodistribution and Uptake Mechanisms of ALS Muscle Exosomes.Vanessa Milla, PhD researcher
Project: Identification of biomarkers to identify ALS subjects among patients affected by motor neuron disorders.Stephen Morgan, PhD researcher
Project: Network medicine to explore the role of muscle exosomes in ALS and other motor neuron disorders.Owen Connolly, PhD researcher
Project: Identification and regulation of toxic elements secreted by ALS vesicles.Dr Bill Duddy, lecturer
My interest in rare diseases stems from the experience of having a brother with the muscle wasting disease, Duchenne muscular dystrophy. This experience pushed me towards a career in science and research. After some 18 years at research institutes in Scotland, the US, and France, I recently returned home to join the University of Ulster’s Northern Ireland Centre for Stratified Medicine. As part of the neuromuscular research group, I am looking for new ways to understand and treat a range of rare conditions affecting the body’s ability to control and maintain its muscle mass. Our focus is on the role of muscle in motor neuron disorders such as Amyotrophic Lateral Sclerosis (ALS).Dr Stéphanie Duguez, senior lecturer, team leader
As a teenager watching the Telethon on French Telethon, I was introduced to neuromuscular conditions and how genetics could help us to understand these diseases and identify therapeutic targets. Ever since then, I have wanted to study neuromuscular disorders, and work as a scientist in this field. During my career, I have worked in different institutes (LPEH Saint Etienne, France, Genethon France, CNMC Washington DC, Institute of Myology, France) on muscle cellular physiology, Duchenne Muscular Dystrophy and then motor neuron diseases. Based at the University of Ulster’s Northern Ireland Centre for Stratified Medicine, I lead the research group in neuromuscular health. Our group focuses on how the muscle communicates with other cells in the body, and its role in motor neuron disorders such as Amyotrophic Lateral Sclerosis (ALS), spinobulbar muscular atrophy (SBMA or Kennedy disease) and SMA-IV.Dr Laura Le Gall
In 2015 I had the chance to join Dr Stephanie Duguez’s lab as part of my Master’s studies, and I quickly developed a particular interest in neuromuscular diseases. Throughout my internship I witnessed the passion for science and research that drives the lab’s work.Thanks to the support of Dr Duguez I obtained a fellowship to start a joint PhD between Sorbonne Universités and Ulster University. My project’s aim was to study the disruption of the intercellular communication between muscle and nerve in ALS patients. In the course this work I investigated the role of muscle in ALS pathology progression via the secretion of extracellular vesicles called exosomes. My project was divided into 3 main sections, 1- I studied the alteration of exosome secretion in ALS muscle cells, 2- I determined the effects of ALS muscle exosomes on neighbouring cells (including muscle cells and motor neurons), and 3- I investigated the mechanisms involved in ALS muscle exosome-mediated toxicity.Dr Geetha Vijayakumar
Dr Apostolos Malatras
Dr Malatras's interests are in the fields of bioinformatics, systems biology, health informatics and biobank informatics. He holds a degree in Computer Science and Biomedical Informatics from University of Thessaly, a MSc in Bioinformatics from University of Athens and a joint PhD in Systems Biology and Bioinformatics, under the supervision of Dr. William Duddy, between Sorbonne University and Free University of Berlin. He has more than 10 years of experience on the proper accumulation, integration, curation, and analysis of omics data. He was in the development team of several online tools and databases, including: HGCA, CellWhere and MyoMiner (https://sys-myo.com/). Until recently, he was a post-doc researcher at Ulster University managing, analyzing, and standardizing clinical and genomic data. He also assisted in development and is the database administrator of related biobanking systems.Dr Lu Zhu
Making sense out of massive biological data by using analytical statistics and machine learning approaches has always been my passion. My training in bioinformatics has granted me essential knowledge in molecular biology, structural biology, and machine learning. My Ph.D. thesis is in the field of systems biology. Currently, I am working on computational molecular design at Valence Discovery.